Chrebp acetylation
WebApr 1, 2024 · Based on these findings, we largely accept the hypothesis that MI may influence SREBP-1c, ChREBP, and histone acetylation of Elovl6 in fatty liver induced … WebBinding levels of ChREBP and SREBP1 to upstream regions of Fasn increased during the suckling-weaning transition. Acetylation of histones H3 and H4 around Fasn increased …
Chrebp acetylation
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WebRecently, the transcription factor ChREBP (carbohydrate-responsive element-binding protein) has emerged as a major mediator of glucose action on lipogenic gene … WebApr 23, 2011 · Interestingly, recent work from our laboratory revealed that ChREBP is regulated by acetylation on specific lysines in response to glucose . In the current study, we report that ChREBP is also subjected to O -GlcNAcylation; O -GlcNAcylation not only stabilizes the protein but also increases its transcriptional activity toward its target genes ...
WebChREBP can also be modified by acetylation via the histone acetyltransferase activity of p300 (Bricambert et al., 2010). Glucose … WebJul 1, 2024 · An increase in ChREBP acetylation in response to glucose may be due to the modulation of acetyltransferase/deacetylase activities. In the current study, we found that …
WebNational Center for Biotechnology Information WebNov 7, 2013 · In this respect, it should be noted that ChREBP activity is increased by acetylation and O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) [67, 68], two enzyme-catalyzed post-translational modifications that use glucose metabolites as substrates, as will be discussed in more detail below [69–71].
WebDietary glucose increasesglucose absorption and lipid deposition via SGLT1/2 signaling and acetylated ChREBP in the intestine and isolated intestinal epithelial cells of yellow catfish. J. ... Cu exposure increased lipid deposition and lipogenesis by affecting Wnt/β-catenin pathway and the β-catenin acetylation levels. Environ.
WebAug 1, 2012 · ChREBP is also regulated by acetylation. HAT activity-containing transcriptional coactivator p300 associates with ChREBP and acetylates Lys672 in the bHLHZ domain and promotes ChREBP DNA binding [36]. ChREBP acetylation by p300 is negatively regulated by salt-inducible kinase 2 (SIK2), which phosphorylates p300. iogp safety performance indicators 2020 pdfWebJun 19, 2024 · Acetylation of ChREBP is known to increase ChREBP transcriptional activity . Indeed, we detected increased ChREBP acetylation in primary hepatocytes isolated from HFrD-fed mice in comparison with regular chow-fed mice (Supplemental Figure 3C), suggesting that fructose feeding also enhances the ChREBP function. ons subscriptionWebGlucose is an energy source that also controls the expression of key genes involved in energetic metabolism through the glucose-signaling transcription factor carbohydrate response element-binding protein (ChREBP). ChREBP has recently emerged as a central regulator of glycolysis and de novo fatty acid synthesis in liver, but new evidence shows … ons sub regional productivityWebMar 11, 2015 · ChREBP Acetylation Relies on EtOH Metabolism Through ADH. To determine whether EtOH metabolism is required for ChREBP acetylation, we performed experiments in mouse hepatocytes in the presence or absence of 4MP, a known ADH inhibitor (Fig. 4). 17 We observed that 4MP treatment totally prevented the EtOH … ons study on flexible workingWebApr 1, 2024 · ChREBP is activated in mice fed chronically with alcohol by a mechanism that involves dephosphorylation of ChREBP through the inhibition of AMPK and protein phosphatase 2A (PP2A) (60). Acute alcohol feeding also increases ChREBP activity via acetylation by SIRT1 (61). In addition, ChREBP silencing prevents ethanol-induced … iogp safety momentsWebFurthermore, we found that the binding of carbohydrate response element binding protein (ChREBP), which is a key transcription factor for the Thrsp gene, and the acetylation of histones H3 and H4, which is one of the histone modifications for transactivation, on the Thrsp gene were reduced by feeding the RS diet. iogp s-611 pdfWebIn another report on histone H3 acetylation it was shown that insulin induced major transcriptional factors such as sterol regulatory element-binding transcription factor 1c (SREBP-1c) and carbohydrate responsive element-binding protein (ChREBP) binding with sterol regulatory elements (SRE) or carbohydrate-responsive elements (ChORE) of the ... iogp security