Helicase blm
WebRecQ-like DNA helicase BLM UniProtKB InterPro STRING Interactive Modelling. 1417 aa; Sequence (Fasta) It is possible new templates exist for this target since these models … WebHelicases are motor proteins that move directionally along a nucleic acid phosphodiester backbone, separating two hybridized nucleic acid strands (hence helic- + -ase ), using energy from ATP hydrolysis. There are …
Helicase blm
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WebRecQ-like DNA helicase BLM Curated EC number EC:3.6.4.12 ( UniProtKB ENZYME Rhea) 2 publications Alternative names Bloom syndrome protein DNA helicase, RecQ … Web29 mrt. 2024 · The Bloom syndrome is an autosomal recessive disorder characterized by growth deficiency, microcephaly and immunodeficiency among others. It is caused by homozygous or compound heterozygous mutation in the gene encoding DNA helicase RecQ protein on chromosome 15q26.
Web6 nov. 2024 · The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination … WebThe Sgs1 helicase is an ortholog of the human Bloom syndrome protein. It appears to be a central regulator of most of the recombination events that occur during S. cerevisiae …
Web29 mrt. 2024 · Downregulation of BLM RecQ helicase inhibits proliferation, promotes the apoptosis and enhances the sensitivity of bladder cancer cells to cisplatin. Phenotypic … WebThe BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. We find that in cells expressing a mutant version of …
Web16 mrt. 2024 · BLM encodes a 3'-5' DNA helicase showing homology to the E. coli RecQ protein (Ellis et al., 1995; Karow et al., 1997). RecQ homologs are evolutionarily highly …
Web13 okt. 2024 · BLM, the RecQ DNA helicase mutated in Bloom syndrome, is preferentially modified by SUMO-2/3 both in vitro and in vivo. Bone marrow cells from mice heterozygous for BLM mutation, BLM (Cin/+), transfected with BCR/ABL display increased sensitivity to cisplatin. observations indicate that Blm is a modifier of tumor formation in the mouse … omaha football scoresWeb21 apr. 2015 · Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism … omaha ford woodhouseWebBLM Helicase. The gene encoding BLM helicase is located on 15q26.1 chromosome in humans and encodes a protein of 1417 amino acids with a molecular weight of 159 kDa. … omaha foot and ankleWeb10 mrt. 2024 · 研究首次揭示了修复型DNA解旋酶Bloom syndrome helicase（BLM）在人类复制蛋白A（human Replication Protein A, hRPA）的协助下，由双链DNA中的单链断 … omaha fort worthWeb19 feb. 2013 · In the January 24, 2013 issue of Chemistry and Biology, Nguyen et al. reported their discovery of a small molecule inhibitor of BLM helicase. 5 From a high throughput screen of a chemical compound library and medicinal chemistry optimization, a small molecule (ML216) was identified that inhibited BLM helicase activity on a forked … omaha football playWebThe two BLM alleles in the resulting cell line KSVS1452 (BLM KO) contain different frameshift mutations that lead to termination at codon 686 upstream of conserved … omaha fox news channelWeb2 dec. 2016 · BLM expression was significantly higher in the poor prognosis proliferation MM subgroup (P < 0.05). Moreover, we found that BLM was overexpressed in HMCLs … omaha foundation