Sacsin molecular chaperone
WebSacsin molecular chaperone: Gene name i. SACS (ARSACS, DKFZp686B15167, DNAJC29, KIAA0730, PPP1R138, SPAX6) Protein class i. Cancer-related genes ... Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other a taxia-linked proteins. ... WebNov 26, 2024 · Sacsin belongs to the HSP40 (40 kDa molecular mass) family that acts as the HSP70 (70 kDa molecular mass) family of co-chaperones 7,8 whereby some of …
Sacsin molecular chaperone
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WebFor example in ARSACS, the deficient sacsin protein-which acts as a chaperone or regulator for the organization of the intermediate filament cytoskeleton (Duncan et al., 2024)-leads to an altered ... WebAug 15, 2024 · Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early-onset neurological disease caused by mutations in SACS, which encodes sacsin. The complex architecture of sacsin suggests that it could be a key player in cellular protein quality control system. Molecular chaperones that operate in protein folding/unfolding …
Webto the action of a set of molecular chaperones located in the cytosol and in the mitochondrial matrix (Table i). Mitochondria represent an attractive system in which to … WebSACS, sacsin molecular chaperone Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog SACS, sacsin molecular chaperone. …
WebApr 9, 2024 · Summary. This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is … WebThe product of this gene is a very large 520 kDa cytoplasmic protein, sacsin, with an ubiquitin-like domain (Ubl) at the N-terminus... Molecular Chaperones, Structural Biology and ...
WebAutosomal recessive spastic ataxia of Charlevoix-Saguenay is a fatal brain disorder featuring cerebellar neurodegeneration leading to spasticity and ataxia. This disease is caused by mutations in the SACS gene that encodes sacsin, a massive 4579-amino acid protein with multiple modular domains. However, molecular details of the function of … manly nrl teamWebThe main function of a class of proteins known as molecular chaperones is to prevent protein misfolding and aggregation. Although neuronal cells contain the major known … kosher richmondWebsacsin molecular chaperone. GO Process (2) GO Function (3) GO Component (6) Gene Ontology Biological Process. negative regulation of inclusion body assembly ; protein folding . Gene Ontology Molecular Function. Hsp70 protein binding ; chaperone binding ; proteasome binding . manly nsw 2095 australiaWebJul 18, 2024 · Autosomal recessive cerebellar ataxias (ARCAs) are a complex group of disabling neurodegenerative disorders that manifest predominantly in childhood and early adulthood [].Despite increasing knowledge regarding the molecular basis of ARCA, a considerable number of patients remain without a specific diagnosis [].The diagnosis is … manly nrl team 2022WebJan 1, 2005 · Molecular chaperones are important for maintaining a functional set of proteins in all cellular compartments. ... The occurrence in sacsin of chaperone markers would suggest that sacsin is a ... manly nsw 14 day weather forecastWebSacsin contains regions of similarity to both molecular chaperones and co-chaperones. Thus, this disease may represent a useful model to study the role of molecular … manly nsw accommodationWebMar 21, 2024 · Complete information for LOC100421658 gene (Pseudogene), Sacsin Molecular Chaperone Pseudogene, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium manly nsw australia