WebbLLC1 lung cancer cell tumors (bottom) were produced by subcutaneous injection of tumor cells in Tie2-CreERT2; Wt1 Lox/Lox mice treated with vehicle (n = 9) or Tie2-CreERT2 animals (n = 8)... Webb9 maj 2024 · Hif1a fl/fl mice (Jackson Lab, Stock #007561) were crossed with Tie2-CreERT2 mice 75 (Jackson Lab, Stock #2450312). Mice were gauge fed with Tamoxifen (20 mg/ml in corn oil) ...
Establishment of a Cre-rat resource for creating conditional and ...
WebbNext, to deter- mine the function of Wt1 expression in MDSCs, we induced LLC1 tumours in Tie2-CreERT2;Wt1 lox/lox and Tie2-CreERT2 animals, and isolated MDSCs from these tumours to knockout Wt1 in ... WebbNext, to deter- mine the function of Wt1 expression in MDSCs, we induced LLC1 tumours in Tie2-CreERT2;Wt1 lox/lox and Tie2-CreERT2 animals, and isolated MDSCs from these … sensory rsc-364
Context-dependent regulation of endothelial cell metabolism
Webb5 nov. 2024 · Finally, we evaluated whether pharmacological inhibition of EphA4 could recapitulate the enhanced collateral remodeling seen in EphA4 fl/fl /Tie2-Cre and EphA4 fl/fl /VeCadherin-CreERT2 mice. To test this, we utilized sub-Q mini-osmotic pump infusion of the EphA4 peptide inhibitor, KYL, which prevents ligand binding and EphA4 activation … Webb4 apr. 2024 · Tg (Tek-cre/ERT2)1Arnd. Mutation details : The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated … WebbMoreover, experiments treating adult Tcf21-MerCreMer, WT1-CreERT2, and Tbx18-CreERT2 mice with tamoxifen showed that only Tcf21 was still expressed in adult cardiac fibroblast while the lineage-traced cells in WT1-CreERT2 and Tbx18-CreERT2 mice were primarily epicardial cells (Moore-Morris et al., 2014), indicating the limitations of some of … sensory rugs for children